药物开发
人类疾病
神经科学
血脑屏障
医学
药品
人脑
疾病
生物
药理学
中枢神经系统
病理
作者
Jeong‐Kee Yoon,Jae-Hoon Kim,Zachary Shah,Ashi Awasthi,Advay Mahajan,Yong Tae Kim
标识
DOI:10.1002/adhm.202002285
摘要
The blood-brain barrier (BBB) is a unique vascular structure that serves as a molecular transport gateway for the maintenance of brain homeostasis. Chronic disruption or breakdown of the BBB reportedly leads to neurodegenerative diseases. Nonetheless, research on human BBB pathophysiology and drug development remains highly dependent on studies using inherently different animals. Moreover, more studies have shown that animal models are not appropriate in modeling Alzheimer's disease (AD), underlining the importance of in vitro models of the human BBB with physiological relevance. In this review, recent advances in human BBB-on-a-chip technologies are highlighted and their potential for pathogenesis studies and drug prescreening for AD treatment are discussed.
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