Who gets the calories? An endothelial checkpoint for fat expansion

MYCT1-IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion and exposes the endothelium as a decisive regulator of systemic energy partitioning, not a passive conduit for nutrient delivery (Wetterwald et al., 2026, https://doi.org/10.1084/jem.20251497).