医学
伊布替尼
套细胞淋巴瘤
癌症研究
内科学
布鲁顿酪氨酸激酶
淋巴瘤
发病机制
免疫学
白血病
酪氨酸激酶
慢性淋巴细胞白血病
受体
作者
Michael Wang,Simon Rule,Peter Martin,André Goy,Rebecca Auer,Brad S. Kahl,Wojciech Jurczak,Ranjana H. Advani,Jorge Romaguera,Michael E. Williams,Jacqueline C. Barrientos,Ewa Chmielowska,John Radford,Stephan Stilgenbauer,Martin Dreyling,W Wiktor-Jędrzejczak,Peter Johnson,Stephen E. Spurgeon,Lei Li,Liang Zhang
标识
DOI：10.1056/nejmoa1306220
摘要
Bruton's tyrosine kinase (BTK) is a mediator of the B-cell–receptor signaling pathway implicated in the pathogenesis of B-cell cancers. In a phase 1 study, ibrutinib, a BTK inhibitor, showed antitumor activity in several types of non-Hodgkin's lymphoma, including mantle-cell lymphoma.
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