前列腺癌
间质细胞
癌症研究
医学
成纤维细胞生长因子受体1
受体酪氨酸激酶
成纤维细胞生长因子
封锁
成纤维细胞生长因子受体
前列腺
受体
淋巴结
癌症
内科学
作者
Xinhai Wan,Paul G. Corn,Jun Yang,Nallasivam Palanisamy,Michael W. Starbuck,Eleni Efstathiou,Elsa M. Li Ning Tapia,Amado J. Zurita,Ana M. Aparicio,Murali K. Ravoori,Elba S. Vázquez,Dan R. Robinson,Yi‐Mi Wu,Xuhong Cao,Matthew K. Iyer,Wallace L. McKeehan,Vikas Kundra,Fen Wang,Patricia Troncoso,Arul M. Chinnaiyan
标识
DOI:10.1126/scitranslmed.3009332
摘要
Dovitinib is therapeutically active in a subset of patients with prostate cancer bone metastases, partly due to blockade of FGFR-mediated stromal-epithelial interactions in the bone microenvironment.
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