抗菌剂
白色念珠菌
化学
四肽
肺炎克雷伯菌
抗菌活性
伊萨丁
立体化学
微生物学
肽
三肽
碳-13核磁共振
铜绿假单胞菌
生物化学
生物
有机化学
细菌
大肠杆菌
基因
遗传学
作者
Rajiv Dahiya,Hemendra Gautam
出处
期刊:Marine Drugs
[MDPI AG]
日期:2010-08-19
卷期号:8 (8): 2384-2394
被引量:30
摘要
The present study deals with the first total synthesis of the proline-rich cyclopolypeptide stylisin 2 via a solution phase technique by coupling of the Boc-l-Pro-l-Ile-l-Pro-OH tripeptide unit with the l-Phe-l-Pro-l-Pro-l-Tyr-OMe tetrapeptide unit, followed by cyclization of the resulting linear heptapeptide fragment. The chemical structure of the finally synthesized peptide was elucidated by FTIR, 1H/13C-NMR and FAB MS spectral data, as well as elemental analyses. The newly synthesized peptide was subjected to antimicrobial screening against eight pathogenic microbes and found to exhibit potent antimicrobial activity against Pseudomonas aeruginosa, Klebsiella pneumoniae and Candida albicans, in addition to moderate antidermatophyte activity against pathogenic Trichophyton mentagrophytes and Microsporum audouinii when compared to standard drugs—gatifloxacin and griseofulvin.
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