化学
甲苯
催化作用
对映体
金属
反应性(心理学)
产量(工程)
稀土
药物化学
对映选择合成
二胺
立体化学
有机化学
冶金
医学
材料科学
替代医学
矿物学
病理
作者
Hui-Fang Song,Yuli Sun,Chengrong Lu,Bei Zhao
标识
DOI:10.1021/acs.joc.2c00342
摘要
Chiral dinuclear rare-earth metal complexes RE2Ln2 (n = 1, RE = Y(1), Eu(2), Nd(3), La(4), Gd(5); n = 2, RE = Eu(6), Gd(7)) stabilized by the corresponding Trost ligands H3L1 or H3L2 (H3L1 = (S,S)-2,6-bis[2-(hydroxydiphenylmethyl)pyrrolidin-1-ylmethyl]-4-methylphenol, H3L2 = (S,S)-2,6-bis[2-(hydroxydiphenylmethyl)pyrrolidin-1-ylmethyl]-4-chlorophenol) were prepared and three unknown complexes 5-7 were characterized by X-ray diffraction analysis. The chiral rare-earth metal complexes 1-7 displayed high reactivity in the asymmetric hydrophosphonylation of α,β-unsaturated ketones, and 5 mol % of complex 7 together with 10 mol % of chiral diamine (1S,2S)-1,2-cyclohexanediamine were proved to be the optimal catalyst combination. Various hydrophosphonylation products with excellent yields and high to excellent enantiomeric excess (ee) values were obtained in toluene (up to 99% yield, >99% ee).
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