生存素
CD8型
免疫系统
癌症研究
结直肠癌
肿瘤抗原
凋亡抑制因子
细胞毒性T细胞
抗原
医学
免疫学
癌症
免疫疗法
细胞凋亡
生物
内科学
程序性细胞死亡
体外
生物化学
作者
Chiara Casati,Piero Dalerba,Licia Rivoltini,Gianfrancesco Gallino,Paola Deho,Francesca Rini,Filiberto Belli,Delia Mezzanzanica,Aurora Costa,Salvatore Andreola,Ermanno Leo,Giorgio Parmiani,Chiara Castelli
出处
期刊:PubMed
日期:2003-08-01
卷期号:63 (15): 4507-15
被引量:28
摘要
The identification of tumor-associated antigens expressed by colorectal carcinoma remains one of the major goals for designing novel immunological treatments for this tumor. By using a reverse-immunology approach, we show here that the inhibitor of apoptosis protein, survivin, is immunogenic in colorectal cancer patients. In particular, we found that survivin elicited CD8(+) T cell-mediated responses in peripheral blood or in tumor-associated lymphocytes from patients at different disease stage. Colorectal carcinoma cells were recognized by survivin-specific T lymphocytes, and the survivin-specific, class-I HLA-restricted T lymphocytes were fully activated and released interleukin-2 in response to HLA/survivin-peptide complexes expressed by tumor cells. In addition to CD8-mediated responses, survivin specifically stimulated CD4+ T-cell reactivity in peripheral blood lymphocytes from the same patients, thus suggesting that a complete activation of the immune system may occur in response to this antiapoptotic protein. These findings indicate that survivin could be considered a valuable tumor-associated antigen for immune-based clinical approaches in colorectal cancer.
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