Biosynthesis and synthesis of biologically active alkaloids of Indian medicinal plants

The structure and stereochemistry of biologically active alkaloids isolated from Croton sparsiflorus, Cocculus taurifolius, C. pendulus, Corydalis meifolia and Stephania glabra were established. Biosynthetic studies were carried out on preaporphine and dihydroproaporphine alkaloids, crotsparine and crotsparinine, and abnormal aporphine alkaloid sparsiflerine; abnormal Erythrina alkaloid isococculidine; morphinan-dienone alkaloid sebiferine; quaternary aporphine bases magnoflorine and laurifoline; bisbenzylisoquinoline alkaloids, pendulin, cocsulinin, (′)-hayatin, (S,R)-hayatidin, (R,R)-isochondrodendrine and (R,R)-bebeerine; biphenylbisbenzylisoquinoline alkaloids tiliacorine, tiliacorinine and tiliageine; aporphine-1-benzylisoquinoline alkaloid thalicarpine; aporphine alkaloid glaucine; and lpecac-β-carboline alkaloid tubulosine. Synthesis of (+)-ophicarpinone, crotsparine, sparsiflorine, tetrahydroprotoberberine alkaloids, (′) scoulerine, (′)-tetrahydropalmatine and their bromo derivatives and biogenetic type synthesis of phenanthroindolizidine alkaloid, tylophorine, seco-phenanthroindolizidine alkaloid, septicin, antofine and alkaloid C, are presented.