This paper discuss other possible approaches to the treatment od Parkinson's disease and parkinsonism, particularly in the case of younger patients. There is no doubt that levodopa treatment has the major advance in the clinical management of parkinsonism patients. However, the artificially of the levodopa decreases after several years and motor complications appear. Precise diagnosis and estimated degree of disease are used before any treatment of parkinsonism. Antiholineregigs or amantadine or dopamine agonists such as pergolide and bromcriptone are highly affective and they can delay the need for the levodopa.