Effects of different means of resuscitation on TNF-α and IL-6 in rats with abdominal infection after hemorrhagic shock

Objective:To observe the effects of different means of resuscitation on TNF-α,IL-6 in rats with abdominal infection after hemorrhagic shock.Methods:Rat models of hemorrhagic shock were reproduced using the modified Capone methods.Fourty six SD rats were randomly divided into two groups:Limited fluid resuscitation group,large quantity fluid rapid resuscitation group(each n=23).Then the blood of loss and the amount of fluid resuscitation,survival rate were observed.Then each group were randomly divided into two different time points abdominal injection of LPS,the contents of TNF-α and IL-6 were measured in 2 h and 4 h.Results:The blood loss and the amount of fluid resuscitation in limited fluid resuscitation group was significantly lower than that in large quantity fluid rapid resuscitation group.The contents of TNF-α and IL-6 of the limited fluid resuscitation group were lower than those in large quantity fluid rapid resuscitation group at the same time(P0.05).Conclusion:The limited fluid resuscitation could obviously reduce the blood loss and mortality,while secondary recovery after abdominal infection,limited fluid resuscitation can reduce the rats TNF-α,IL-6 levels.