Objective To summarize the research progress of zein in pharmaceutics in order to give the more knowledge about zein and broaden application of zein in pharmaceutics.Methods Reviews were done based on relative references about zein.Results With the solvent ethanol and water evaporation,zein self-assembly formed monodisperse microsphere,microsphere film or film.The microspheres can be used in modified-release field and targerted drug delivery,to solid the liquid drug and improve drug stability and bioavailability.Films can be used as isolation layer and stent coatings.In situ gel was effective in the treatment of tumor embolism.Conclusion Zein has a broad development and application prospects in pharmaceutics.