Case-control Study on Relationship Between Pre-pregnancy and Early Pregnancy Diseases and Congenital Heart Disease

Objective To explore the relationship between pre-pregnancy and early pregnancy diseases and congenital heart disease.Methods A hospital-based case-control study was conducted.123 mothers in the case group and 246 mothers in the control group were enrolled and interviewed by questionnaires.Multi-factor non-conditional Logistic regression model was used to analyze the effects of pre-pregnancy and early pregnancy diseases on congenital heart disease.Results Pre-pregnancy and early pregnancy diseases,such as chronic diseases before pregnancy,flu in the early stage of pregnancy,pre-reproductive tract infections in the early stage of pregnancy or before pregnancy,and abnormal reproductive history,would increase the risk of congenital heart disease.Their OR values were 3.084(95% CI: 0.826~11.513),2.023(95% CI: 1.220~2.353),1.750(95% CI: 1.026~2.986),3.617(95% CI: 1.488~8.792),respectively.Conclusions Pre-pregnancy and early pregnancy diseases are associated with congenital heart disease.It is very important to prevent and treat pre-pregnancy and early pregnancy diseases in controlling congenital heart disease.