PTEN公司
生物
自噬
PI3K/AKT/mTOR通路
细胞生物学
蛋白激酶B
抑制器
调节器
癌症研究
糖酵解
新陈代谢
信号转导
生物化学
细胞凋亡
基因
作者
S. Joseph Endicott,Richard A. Miller
出处
期刊:Autophagy
[Informa]
日期:2023-09-08
卷期号:20 (1): 216-217
标识
DOI:10.1080/15548627.2023.2255966
摘要
ABSTRACTPTEN is a negative modulator of the INS-PI3K-AKT pathway and is an essential regulator of metabolism and cell growth. PTEN is one of the most commonly mutated tumor suppressors in cancer. However, PTEN overexpression extends the lifespan of both sexes of mice. We recently showed that PTEN is necessary and sufficient to activate chaperone-mediated autophagy (CMA) in the mouse liver and cultured cells. Selective protein degradation via CMA is required to suppress glycolysis and fatty acid synthesis when PTEN is overexpressed. Thus, activation of CMA downstream of PTEN might modulate health and metabolism through selective degradation of key metabolic enzymes.KEYWORDS: Agingautophagychaperone-mediated autophagymetabolismPTEN Disclosure statementThe authors have no financial conflicts of interest to disclose.Additional informationFundingThis work was supported by U01-AG022303-18 and U19-AG023122-11 to RAM, by 5P30-AG024824 to Raymond Yung and with sub-awards to SJE, by the Hevolution Foundation grant HF-AGE005 to SJE.
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