实体瘤
癌症研究
细胞疗法
电流(流体)
癌症治疗
免疫学
医学
癌症
计算生物学
细胞
生物
内科学
生物化学
物理
热力学
作者
Aurore Dougé,Nathan El-Ghazzi,Richard Lemal,Paul Rouzaire
出处
期刊:Molecular Cancer Therapeutics
[American Association for Cancer Research]
日期:2024-01-18
卷期号:: OF1-OF13
标识
DOI:10.1158/1535-7163.mct-23-0310
摘要
Abstract In solid tumors, three main complementary approaches of adoptive T-cell therapies were successively developed: tumor-infiltrating lymphocytes, chimeric antigen receptor engineered T cells, and high-affinity T-cell receptor engineered T cells. In this review, we summarized rational and main results of these three adoptive T-cell therapies in solid tumors field and gave an overview of encouraging data and their limits. Then, we listed the major remaining challenges (including tumor antigen loss, on-target/off-tumor effect, tumor access difficulties and general/local immunosubversion) and their lines of research. Finally, we gave insight into the ongoing trials in solid tumor.
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