One‐Pot Synthesis of Quinazolines via Elemental Sulfur‐Mediated Oxidative Condensation of Nitriles and 2‐(Aminomethyl)anilines

Abstract A strategy for the synthesis of quinazolines via elemental sulfur‐mediated oxidative condensation of nitriles and 2‐(aminomethyl)anilines was developed. The reaction was carried out under metal‐/solvent‐free conditions, tolerates a wide range of functional groups to provide the corresponding products in 56%‐91% yield, and can be performed on a gram‐scale. The UV/Vis absorption and fluorescence spectra of several product derivatives were measured to study their photophysical properties. magnified image