光热治疗
材料科学
癌细胞
癌症研究
纳米载体
光热效应
纳米晶
癌症
免疫原性细胞死亡
纳米技术
阿霉素
生物物理学
纳米颗粒
生物
化疗
遗传学
作者
Baochan Yang,Yiming Zhang,Lixin Sun,Jian Wang,Zunling Zhao,Zhuoyue Huang,Wei Mao,Rong Xue,Runsheng Chen,Jianjun Luo,Tianyu Wang,Jianzhuang Jiang,Yan Qin
标识
DOI:10.1002/adfm.202211251
摘要
Abstract Ferroptosis is recently discovered programmed cell death, induced by cellular ferrous ion bursts and subsequent Fenton reactions. The iron source in tumor cells is limited due to tightly controlled iron metabolism. Since hierarchical iron architecture is rarely considered in ferroptosis cancer treatment, multilayer Fe 2 O 3 architectures (UF@PPDF NPs) are developed by modulating ultra‐small γ‐Fe 2 O 3 nanocrystal assemblies, and further conjugating cancer cell targeting folic acid (FA), chemotherapeutic drug doxorubicin (Dox). Hierarchically assembled γ‐Fe 2 O 3 nanocrystal facilitates switchable magnetic resonance imaging (MRI), much enhanced ferroptosis efficiency, and very high second near‐infrared (NIR‐II) photothermal conversion. For MRI, UF@PPDF nanoparticles (NPs) enables clearly visualized tissues in terms of size and compactness, with dynamic T2‐T1 imaging switching. UF@PPDF NPs exhibits highly efficient photothermal therapy (PTT) upon NIR‐II irradiation, together with controlled release of ferric ions and Dox, thus achieving PTT‐chemotherapy‐ferroptosis trifunctional synergistic cancer therapy for tumor ablation. RNA sequencing analyses of differentially expressed genes implies a multifaceted role for this therapy in cancer cell signaling. Cellular respiration and electron transport are significantly upregulated, while the epigenetic pathways, including chromatin modification and RNA transcription activity are severely downregulated, with an overall effect of cellular apoptosis. Thus, γ‐Fe 2 O 3 architectures provide new possibility for highly efficient deep tumor treatment.
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