自噬
癌症研究
体内
癌细胞
癌症
化学
羟基氯喹
细胞凋亡
医学
生物
内科学
生物化学
疾病
生物技术
2019年冠状病毒病(COVID-19)
传染病(医学专业)
作者
Ruihao Qian,Guoliang Cao,Wen Su,Jie Zhang,Yue Jiang,Haohao Song,Fuhao Jia,Hai Wang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2022-11-07
卷期号:22 (22): 9154-9162
被引量:8
标识
DOI:10.1021/acs.nanolett.2c03890
摘要
Autophagy is one of the key pathways for tumor cell survival and proliferation. Therefore, inhibition of autophagy has been extensively studied for cancer therapy. However, current autophagy inhibitors lack specificity and are ineffective in limiting tumor progression. Herein, we report a nanoplatform for tumor-site-targeted delivery of hydroxychloroquine (HCQ) using insulin-like growth factors 2 receptor (IGF2R)-targeted liposomes (iLipo-H). A fasting-mimicking diet (FMD) is used to increase the autophagy levels in tumor cells, thereby increasing the sensitivity of tumor cells to HCQ. In addition, FMD treatment upregulates the expression of IGF2R in tumor cells, but not normal cells. Consequently, iLipo-H nanoparticles efficiently accumulate at the tumor site under FMD condition. In vivo studies demonstrate that iLipo-H nanoparticles efficiently inhibit 4T1 tumor growth without obvious side effects, especially under FMD condition. This study provides a promising strategy to increase the sensitivity of tumor cells to autophagy inhibitors for effective cancer therapy.
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