化学
催化作用
区域选择性
分子氧
组合化学
配体(生物化学)
基质(水族馆)
过渡金属
氧气
绿色化学
有机化学
反应机理
生物化学
海洋学
受体
地质学
作者
Daoming Wang,Li-Qin She,Hao Yuan,Yichen Wu,Yong Tang,Peng Wang
标识
DOI:10.1002/anie.202304573
摘要
The use of molecular oxygen as the terminal oxidant in transition metal catalyzed oxidative process is an appealing and challenging task in organic synthetic chemistry. Here, we report a Ni-catalyzed hydroxylarylation of unactivated alkenes enabled by a β-diketone ligand with high efficiency and excellent regioselectivity employing molecular oxygen as the oxidant and hydroxyl source. This reaction features mild conditions, broad substrate scope and incredible heterocycle compatibility, providing a variety of β-hydroxylamides, γ-hydroxylamides, β-aminoalcohols, γ-aminoalcohols, and 1,3-diols in high yields. The synthetic value of this methodology was demonstrated by the efficient synthesis of two bioactive compounds, (±)-3'-methoxyl citreochlorol and tea catechin metabolites M4.
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