医学
内科学
转移性乳腺癌
肿瘤科
乳腺癌
回顾性队列研究
无进展生存期
癌症
胃肠病学
联合疗法
化疗
作者
Erol Yıldırım,Elif Atağ,Ezgi Çoban,Olçun Ümit Ünal,Abdüssamet Çelebi,Murat Keser,Mehmet Uzun,Merve Keskinkılıç,Eda Tanrikulu Şimşek,Murat Sarı,Tuğba Yavuzşen
出处
期刊:The Breast
[Elsevier]
日期:2023-08-01
卷期号:70: 56-62
被引量:3
标识
DOI:10.1016/j.breast.2023.06.006
摘要
CDK4/6 inhibitors combined with endocrine therapy have significantly improved treatment outcomes for metastatic hormone receptor-positive (HR+) breast cancer patients. However, the impact of low HER2 expression on treatment response and progression-free survival (PFS) remains unclear.This multicenter retrospective study included 204 HR+ breast cancer patients treated with a combination of CDK4/6 inhibitor and endocrine therapy. HER2-zero disease was detected in 138 (68%) and HER2-low disease in 66 (32%) patients. Treatment-related characteristics and clinical outcomes were analyzed, with a median follow-up of 22 months.The objective response rate (ORR) was 72.7% in the HER2 low group and 66.6% in the HER2 zero group (p = 0.54). Median PFS was not significantly different between the HER2-low and HER2 zero groups (19 months vs.18 months, p = 0.89), although there was a trend toward longer PFS in the HER2-low group for first-line treatment (24 months progression-free survival rate 63% vs 49%). In recurrent disease, the median PFS was 25 months in the HER2-low group and 12 months in the HER2-zero group (p = 0.08), while in de novo metastatic disease, the median PFS was 18 months in the HER2-low group and 27 months in the HER2-zero group (p = 0.16). The order of CDK4/6 inhibitor use and the presence of visceral metastasis were identified as independent variables affecting PFS.Low HER2 expression did not significantly impact treatment response or PFS in HR+ breast cancer patients treated with a CDK4/6 inhibitor and endocrine therapy. Because of the conflicting results in the literature, further prospective studies are needed to evaluate the clinical significance of HER2 expression in HR+ breast cancer.
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