TOPAZ-1: a new standard of care for advanced biliary tract cancers?

护理标准 内科学 胆道 医学 黄玉 肿瘤科 普通外科 生物 古生物学
作者
Matthew I. Ebia,K. Nathan Sankar,Arsen Osipov,Andrew Eugene Hendifar,Jun Gong
出处
期刊:Immunotherapy [Future Medicine]
卷期号:15 (7): 473-476 被引量:1
标识
DOI:10.2217/imt-2022-0269
摘要

ImmunotherapyVol. 15, No. 7 EditorialTOPAZ-1: a new standard of care for advanced biliary tract cancers?Matthew I Ebia, Kamya Sankar, Arsen Osipov, Andrew E Hendifar & Jun GongMatthew I Ebia https://orcid.org/0000-0001-7159-1926Department of Medicine, Division of Hematology & Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USASearch for more papers by this author, Kamya SankarDepartment of Medicine, Division of Hematology & Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USACedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA 90048, USASearch for more papers by this author, Arsen OsipovDepartment of Medicine, Division of Hematology & Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USACedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA 90048, USASearch for more papers by this author, Andrew E HendifarDepartment of Medicine, Division of Hematology & Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USACedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA 90048, USASearch for more papers by this author & Jun Gong*Author for correspondence: E-mail Address: jun.gong@cshs.orgDepartment of Medicine, Division of Hematology & Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USACedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA 90048, USASearch for more papers by this authorPublished Online:23 Mar 2023https://doi.org/10.2217/imt-2022-0269AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: biliary tract cancercancer survivalcheckpoint inhibitorschemotherapycholangiocarcinomaReferences1. Banales JM, Marin JJG, Lamarca A et al. Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Nat. Rev. Gastroenterol. Hepatol. 17(9), 557–588 (2020).Crossref, Medline, Google Scholar2. Valle J, Wasan H, Palmer DH et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N. Engl. J. Med. 362(14), 1273–1281 (2010).Crossref, Medline, CAS, Google Scholar3. Oh D-Y, He AR, Qin S et al. Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer. NEJM Evidence 1(8), EVIDoa2200015 (2022).Crossref, Google Scholar4. Burns HA 3rd, Okusaka T, Vogel A et al. Patient-reported outcomes for the phase 3 TOPAZ-1 study of durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer. J. Clin. Oncol. 40(Suppl.16), 4070 (2022).Google Scholar5. Vogel A, Boeck S, Waidmann O et al. 52MO A randomized phase II trial of durvalumab and tremelIMUmab with gemcitabine or gemcitabine and cisplatin compared to gemcitabine and cisplatin in treatment-naïve patients with CHolangio- and gallbladdEr Carcinoma (IMMUCHEC). Ann. Oncol. 33, S563 (2022).Medline, Google Scholar6. Rizzo A, Ricci AD, Brandi G. Durvalumab: an investigational anti-PD-L1 antibody for the treatment of biliary tract cancer. Expert Opin. Investig. Drugs 30(4), 343–350 (2021).Crossref, Medline, CAS, Google Scholar7. Ricci AD, Rizzo A, Brandi G. The DNA damage repair (DDR) pathway in biliary tract cancer (BTC): a new Pandora’s box? ESMO Open 5(5), e001042 (2020).Crossref, Medline, Google Scholar8. Gandhi L, Rodriguez-Abreu D, Gadgeel S et al. Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N. Engl. J. Med. 378(22), 2078–2092 (2018).Crossref, Medline, CAS, Google Scholar9. Gadgeel S, Rodriguez-Abreu D, Speranza G et al. Updated analysis from KEYNOTE-189: pembrolizumab or placebo plus pemetrexed and platinum for previously untreated metastatic nonsquamous non-small-cell lung cancer. J. Clin. Oncol. 38(14), 1505–1517 (2020).Crossref, Medline, CAS, Google Scholar10. Burtness B, Harrington KJ, Greil R et al. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study. Lancet 394(10212), 1915–1928 (2019).Crossref, Medline, CAS, Google Scholar11. Harrington KJ, Burtness B, Greil R et al. Pembrolizumab with or without chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma: updated results of the phase III KEYNOTE-048 study. J. Clin. Oncol. 41(4), 790–802 (2022).Crossref, Medline, Google Scholar12. Powles T, Park SH, Voog E et al. Avelumab maintenance therapy for advanced or metastatic urothelial carcinoma. N. Engl. J. Med. 383(13), 1218–1230 (2020).Crossref, Medline, CAS, Google Scholar13. Sahai V, Griffith KA, Beg MS et al. A randomized phase 2 trial of nivolumab, gemcitabine, and cisplatin or nivolumab and ipilimumab in previously untreated advanced biliary cancer: BilT-01. Cancer 128(19), 3523–3530 (2022).Crossref, Medline, CAS, Google Scholar14. Shroff RT, Guthrie KA, Scott AJ et al. SWOG 1815: a phase III randomized trial of gemcitabine, cisplatin, and nab-paclitaxel versus gemcitabine and cisplatin in newly diagnosed, advanced biliary tract cancers. J. Clin. Oncol. 41(Suppl. 4), LBA490–LBA490 (2023).Google Scholar15. Shroff RT, Javle MM, Xiao L et al. Gemcitabine, cisplatin, and nab-paclitaxel for the treatment of advanced biliary tract cancers: a phase 2 clinical trial. JAMA Oncol. 5(6), 824–830 (2019).Crossref, Medline, Google Scholar16. Schizas D, Mastoraki A, Routsi E et al. Combined hepatocellular-cholangiocarcinoma: an update on epidemiology, classification, diagnosis and management. Hepatobiliary Pancreat. Dis. Int. 19(6), 515–523 (2020).Crossref, Medline, Google Scholar17. Finn RS, Qin S, Ikeda M et al. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. N. Engl. J. Med. 382(20), 1894–1905 (2020).Crossref, Medline, CAS, Google Scholar18. Nguyen CT, Caruso S, Maille P et al. Immune profiling of combined hepatocellular-cholangiocarcinoma reveals distinct subtypes and activation of gene signatures predictive of response to immunotherapy. Clin. Cancer Res. 28(3), 540–551 (2022).Crossref, Medline, CAS, Google Scholar19. Chakrabarti S, Kamgar M, Mahipal A. Targeted therapies in advanced biliary tract cancer: an evolving paradigm. Cancers (Basel) 12(8), 2039 (2020).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 15, No. 7 STAY CONNECTED Metrics Downloaded 144 times History Received 25 October 2022 Accepted 14 February 2023 Published online 23 March 2023 Published in print May 2023 Information© 2023 Future Medicine LtdKeywordsbiliary tract cancercancer survivalcheckpoint inhibitorschemotherapycholangiocarcinomaAuthor contributionsM Ebia contributed to the writing, original draft preparation, reviewing and editing. K Sankar contributed to writing, reviewing and editing. A Osipov contributed to writing, reviewing and editing. A Hendifar contributed to writing, reviewing and editing. J Gong contributed to conceptualization, writing, reviewing and editing.Financial & competing interests disclosureJ Gong is a consultant or has an advisory role for the following institutions; EMD Serono, Elsevier, Exelixis, QED Therapeutics, Natera, Basilea, HalioDx, Eisai, Janssen, Myovant, Astellas and Amgen. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小为发布了新的文献求助10
刚刚
刚刚
1秒前
zhangzhang完成签到,获得积分10
1秒前
盛夏如花发布了新的文献求助30
2秒前
2秒前
3秒前
imka发布了新的文献求助10
3秒前
完美世界应助意大利面采纳,获得10
3秒前
科研通AI2S应助做实验的猹采纳,获得10
4秒前
Nicole完成签到,获得积分10
4秒前
4秒前
5秒前
HongYanCui完成签到,获得积分10
5秒前
5秒前
李亚静发布了新的文献求助10
5秒前
Guts发布了新的文献求助10
6秒前
stella发布了新的文献求助10
6秒前
6秒前
7秒前
7秒前
30完成签到,获得积分10
7秒前
领导范儿应助飞0802采纳,获得10
7秒前
小摩尔发布了新的文献求助10
7秒前
研友_LwbGg8完成签到,获得积分10
7秒前
李健的小迷弟应助大溺采纳,获得10
7秒前
FashionBoy应助海德堡采纳,获得10
8秒前
我是老大应助张晓倩采纳,获得10
8秒前
HongYanCui发布了新的文献求助10
8秒前
zyh完成签到,获得积分10
8秒前
valimar完成签到,获得积分10
8秒前
8秒前
Tong完成签到,获得积分10
9秒前
阿金发布了新的文献求助10
9秒前
ding发布了新的文献求助10
9秒前
小二郎应助zhangzhang采纳,获得10
9秒前
9秒前
9秒前
DUDUBAOLE发布了新的文献求助10
9秒前
咿呀咿呀哟完成签到,获得积分10
9秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Introducing the Learning Sciences 1000
2026年中国辛酸癸酸聚乙二醇甘油酯行业市场现状调查及投资机会研判报告 1000
2026年中国辛酸癸酸聚乙二醇甘油酯行业市场规模及竞争格局分析报告 1000
Resiliency Scale for Adolescents--Chinese Version 800
48V Low-voltage Power Distribution Network (PDN) Architecture Industry Report, 2024 800
Fundamentals of Pharmaceutical and Biologics Regulations: A Global Perspective, Second Edition 700
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 内科学 物理 复合材料 催化作用 细胞生物学 无机化学 光电子学 物理化学 电极 基因
热门帖子
关注 科研通微信公众号,转发送积分 7324894
求助须知:如何正确求助?哪些是违规求助? 8940274
关于积分的说明 18956752
捐赠科研通 6981684
什么是DOI,文献DOI怎么找? 3215499
关于科研通互助平台的介绍 2382798
邀请新用户注册赠送积分活动 2194821