亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

TOPAZ-1: a new standard of care for advanced biliary tract cancers?

护理标准 内科学 胆道 医学 黄玉 肿瘤科 普通外科 生物 古生物学
作者
Matthew I. Ebia,K. Nathan Sankar,Arsen Osipov,Andrew Eugene Hendifar,Jun Gong
出处
期刊:Immunotherapy [Future Medicine]
卷期号:15 (7): 473-476 被引量:1
标识
DOI:10.2217/imt-2022-0269
摘要

ImmunotherapyVol. 15, No. 7 EditorialTOPAZ-1: a new standard of care for advanced biliary tract cancers?Matthew I Ebia, Kamya Sankar, Arsen Osipov, Andrew E Hendifar & Jun GongMatthew I Ebia https://orcid.org/0000-0001-7159-1926Department of Medicine, Division of Hematology & Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USASearch for more papers by this author, Kamya SankarDepartment of Medicine, Division of Hematology & Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USACedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA 90048, USASearch for more papers by this author, Arsen OsipovDepartment of Medicine, Division of Hematology & Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USACedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA 90048, USASearch for more papers by this author, Andrew E HendifarDepartment of Medicine, Division of Hematology & Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USACedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA 90048, USASearch for more papers by this author & Jun Gong*Author for correspondence: E-mail Address: jun.gong@cshs.orgDepartment of Medicine, Division of Hematology & Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USACedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA 90048, USASearch for more papers by this authorPublished Online:23 Mar 2023https://doi.org/10.2217/imt-2022-0269AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: biliary tract cancercancer survivalcheckpoint inhibitorschemotherapycholangiocarcinomaReferences1. Banales JM, Marin JJG, Lamarca A et al. Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Nat. Rev. Gastroenterol. Hepatol. 17(9), 557–588 (2020).Crossref, Medline, Google Scholar2. Valle J, Wasan H, Palmer DH et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N. Engl. J. Med. 362(14), 1273–1281 (2010).Crossref, Medline, CAS, Google Scholar3. Oh D-Y, He AR, Qin S et al. Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer. NEJM Evidence 1(8), EVIDoa2200015 (2022).Crossref, Google Scholar4. Burns HA 3rd, Okusaka T, Vogel A et al. Patient-reported outcomes for the phase 3 TOPAZ-1 study of durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer. J. Clin. Oncol. 40(Suppl.16), 4070 (2022).Google Scholar5. Vogel A, Boeck S, Waidmann O et al. 52MO A randomized phase II trial of durvalumab and tremelIMUmab with gemcitabine or gemcitabine and cisplatin compared to gemcitabine and cisplatin in treatment-naïve patients with CHolangio- and gallbladdEr Carcinoma (IMMUCHEC). Ann. Oncol. 33, S563 (2022).Medline, Google Scholar6. Rizzo A, Ricci AD, Brandi G. Durvalumab: an investigational anti-PD-L1 antibody for the treatment of biliary tract cancer. Expert Opin. Investig. Drugs 30(4), 343–350 (2021).Crossref, Medline, CAS, Google Scholar7. Ricci AD, Rizzo A, Brandi G. The DNA damage repair (DDR) pathway in biliary tract cancer (BTC): a new Pandora’s box? ESMO Open 5(5), e001042 (2020).Crossref, Medline, Google Scholar8. Gandhi L, Rodriguez-Abreu D, Gadgeel S et al. Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N. Engl. J. Med. 378(22), 2078–2092 (2018).Crossref, Medline, CAS, Google Scholar9. Gadgeel S, Rodriguez-Abreu D, Speranza G et al. Updated analysis from KEYNOTE-189: pembrolizumab or placebo plus pemetrexed and platinum for previously untreated metastatic nonsquamous non-small-cell lung cancer. J. Clin. Oncol. 38(14), 1505–1517 (2020).Crossref, Medline, CAS, Google Scholar10. Burtness B, Harrington KJ, Greil R et al. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study. Lancet 394(10212), 1915–1928 (2019).Crossref, Medline, CAS, Google Scholar11. Harrington KJ, Burtness B, Greil R et al. Pembrolizumab with or without chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma: updated results of the phase III KEYNOTE-048 study. J. Clin. Oncol. 41(4), 790–802 (2022).Crossref, Medline, Google Scholar12. Powles T, Park SH, Voog E et al. Avelumab maintenance therapy for advanced or metastatic urothelial carcinoma. N. Engl. J. Med. 383(13), 1218–1230 (2020).Crossref, Medline, CAS, Google Scholar13. Sahai V, Griffith KA, Beg MS et al. A randomized phase 2 trial of nivolumab, gemcitabine, and cisplatin or nivolumab and ipilimumab in previously untreated advanced biliary cancer: BilT-01. Cancer 128(19), 3523–3530 (2022).Crossref, Medline, CAS, Google Scholar14. Shroff RT, Guthrie KA, Scott AJ et al. SWOG 1815: a phase III randomized trial of gemcitabine, cisplatin, and nab-paclitaxel versus gemcitabine and cisplatin in newly diagnosed, advanced biliary tract cancers. J. Clin. Oncol. 41(Suppl. 4), LBA490–LBA490 (2023).Google Scholar15. Shroff RT, Javle MM, Xiao L et al. Gemcitabine, cisplatin, and nab-paclitaxel for the treatment of advanced biliary tract cancers: a phase 2 clinical trial. JAMA Oncol. 5(6), 824–830 (2019).Crossref, Medline, Google Scholar16. Schizas D, Mastoraki A, Routsi E et al. Combined hepatocellular-cholangiocarcinoma: an update on epidemiology, classification, diagnosis and management. Hepatobiliary Pancreat. Dis. Int. 19(6), 515–523 (2020).Crossref, Medline, Google Scholar17. Finn RS, Qin S, Ikeda M et al. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. N. Engl. J. Med. 382(20), 1894–1905 (2020).Crossref, Medline, CAS, Google Scholar18. Nguyen CT, Caruso S, Maille P et al. Immune profiling of combined hepatocellular-cholangiocarcinoma reveals distinct subtypes and activation of gene signatures predictive of response to immunotherapy. Clin. Cancer Res. 28(3), 540–551 (2022).Crossref, Medline, CAS, Google Scholar19. Chakrabarti S, Kamgar M, Mahipal A. Targeted therapies in advanced biliary tract cancer: an evolving paradigm. Cancers (Basel) 12(8), 2039 (2020).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 15, No. 7 STAY CONNECTED Metrics Downloaded 144 times History Received 25 October 2022 Accepted 14 February 2023 Published online 23 March 2023 Published in print May 2023 Information© 2023 Future Medicine LtdKeywordsbiliary tract cancercancer survivalcheckpoint inhibitorschemotherapycholangiocarcinomaAuthor contributionsM Ebia contributed to the writing, original draft preparation, reviewing and editing. K Sankar contributed to writing, reviewing and editing. A Osipov contributed to writing, reviewing and editing. A Hendifar contributed to writing, reviewing and editing. J Gong contributed to conceptualization, writing, reviewing and editing.Financial & competing interests disclosureJ Gong is a consultant or has an advisory role for the following institutions; EMD Serono, Elsevier, Exelixis, QED Therapeutics, Natera, Basilea, HalioDx, Eisai, Janssen, Myovant, Astellas and Amgen. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
mengliu完成签到,获得积分10
2分钟前
gk123kk完成签到,获得积分10
2分钟前
4分钟前
py999发布了新的文献求助10
4分钟前
gszy1975完成签到,获得积分10
5分钟前
科研通AI2S应助ektyz采纳,获得10
6分钟前
坚强的广山完成签到,获得积分0
6分钟前
褚明雪完成签到 ,获得积分10
7分钟前
自然的含蕾完成签到 ,获得积分10
8分钟前
科研通AI2S应助jyy采纳,获得10
8分钟前
8分钟前
9分钟前
9分钟前
py999发布了新的文献求助10
9分钟前
懂懂发布了新的文献求助10
9分钟前
9分钟前
loulan完成签到,获得积分10
10分钟前
krajicek完成签到,获得积分10
10分钟前
10分钟前
懂懂完成签到,获得积分10
11分钟前
huvy完成签到 ,获得积分10
11分钟前
zsmj23完成签到 ,获得积分0
11分钟前
13分钟前
奋斗刺猬完成签到,获得积分10
14分钟前
17分钟前
lod完成签到,获得积分10
17分钟前
Thermalwave完成签到 ,获得积分10
17分钟前
啊啊啊啊啊啊啊啊啊啊完成签到 ,获得积分10
17分钟前
SCI的芷蝶完成签到 ,获得积分10
17分钟前
ach发布了新的文献求助10
18分钟前
18分钟前
19分钟前
Maolin完成签到 ,获得积分10
20分钟前
jyy发布了新的文献求助10
20分钟前
Hello应助aa采纳,获得30
20分钟前
20分钟前
白云朵儿发布了新的文献求助10
20分钟前
20分钟前
ektyz发布了新的文献求助10
20分钟前
aa发布了新的文献求助30
20分钟前
高分求助中
Un calendrier babylonien des travaux, des signes et des mois: Séries iqqur îpuš 1036
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 1000
Corrosion and Oxygen Control 600
Heterocyclic Stilbene and Bibenzyl Derivatives in Liverworts: Distribution, Structures, Total Synthesis and Biological Activity 500
重庆市新能源汽车产业大数据招商指南(两链两图两池两库两平台两清单两报告) 400
Division and square root. Digit-recurrence algorithms and implementations 400
行動データの計算論モデリング 強化学習モデルを例として 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2545664
求助须知:如何正确求助?哪些是违规求助? 2175642
关于积分的说明 5600192
捐赠科研通 1896371
什么是DOI,文献DOI怎么找? 946248
版权声明 565379
科研通“疑难数据库(出版商)”最低求助积分说明 503557