工程类
制造工程
系统工程
工作(物理)
计算机科学
3D生物打印
纳米技术
生物相容性材料
3D打印
生化工程
作者
Jones Joseph Jebaraj Dharmaraj,N. Rajesh Jesudoss Hynes,Grzegorz Królczyk,Shenbaga Velu Pitchumani
出处
期刊:Machines
[Multidisciplinary Digital Publishing Institute]
日期:2024-07-30
卷期号:12 (8): 518-518
被引量:5
标识
DOI:10.3390/machines12080518
摘要
Three-dimensional (3D) bioprinting has emerged as a revolutionary approach in the life sciences, combining multiple disciplines such as computer engineering, materials science, robotics, and biomedical engineering. This innovative technology enables the production of cellular constructs using bio-inks, and differs from conventional 3D printing by incorporating living cells. The present work addresses the conversion of a commercial thermoplastic 3D printer into a low-cost bioprinter. The modification addresses the challenges of the high cost of commercial bioprinters, limited adaptability, and specialized personnel requirements. This modification uses an extrusion-based bioprinting method that is particularly popular in research due to its viscosity tolerance and versatility. The individual steps, including replacing the extruder with a syringe pump, rebuilding the electronic motherboard, and configuring the firmware, are explained in detail. The work aims at providing access to bioprinting technology so that laboratories with modest resources can take advantage of the immense potential of this technology. This modification resulted in improved resolution, allowing submicron movements, which is comparable to some of the commercially available bioprinters. The accuracy of the modified printer was validated using hydrogel bioprinting tests, suggesting that it is suitable for broader applications in regenerative medicine.
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