Versatile 3D Printing Scaffold with Spatiotemporal Release of Multiple Drugs for Bone Regeneration

with the decomposition of LDHs. Also noteworthy, we found that eugenol, DMOG, and LDHs exert synergistic effects in promoting the proliferation, angiogenesis, and osteogenic differentiation of cells in vitro, as well as accelerating vascularized bone formation in vivo. This work presents an approach to fabricating 3D-printed scaffolds with spatiotemporal release capabilities for multiple drugs, advancing bone repair.