肝细胞癌
免疫疗法
肿瘤微环境
医学
免疫抑制
癌症研究
CD8型
T细胞
免疫检查点
免疫学
生物
免疫系统
作者
Aldo Prawira,Hang Xu,Yu Mei,Wei Qiang Leow,N. Jannah M. Nasir,Marie J. Y. Reolo,Masayuki Otsuka,Mohammad Rahbari,Ziyao Chen,Madhushanee Weerasooriya,Liyana Bte Abdullah,Jiawei Wu,Sharifah Nur Hazirah,Martin Wasser,Alexander Yaw Fui Chung,Brian K. P. Goh,Pierce K. H. Chow,Salvatore Albani,Joycelyn Jie Xin Lee,Tony Kiat Hon Lim
出处
期刊：Gut
[BMJ]
日期：2025-07-22
卷期号：75 (1): 105-118
被引量：9
标识
DOI：10.1136/gutjnl-2025-335084
摘要
This study uncovers critical immune and metabolic adaptations in SLD-HCC, identifying TNFSF14-TNFRSF14 signalling as a key driver of immunotherapy resistance. Targeting this signalling axis enhances antitumour immunity and improves immunotherapy efficacy, offering a promising therapeutic strategy for SLD-HCC.
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(2025-6-4)
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