癌症
药物反应
抗癌药物
计算机科学
药品
计算生物学
医学
生物
人工智能
药理学
内科学
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2024-04-08
标识
DOI:10.1158/0008-5472.can-24-1123
摘要
Abstract The intersection of precision medicine and artificial intelligence (AI) holds profound implications for cancer treatment, with the potential to significantly advance our understanding of drug responses based on the intricate architecture of tumor cells. A recent study by Park and colleagues titled "A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors," epitomizes this intersection by leveraging an interpretable deep learning model grounded in a comprehensive map of multiprotein assemblies in cancer, known as Nested Systems in Tumors (NeST). This study not only elucidates mechanisms underlying the response to CDK4/6 inhibitors in breast cancer therapy but also highlights the critical role of model interpretability leading to new mechanistic insights.
科研通智能强力驱动
Strongly Powered by AbleSci AI