立体中心
阿托品
对映选择合成
钯
立体选择性
化学
催化作用
劈理(地质)
键裂
立体化学
有机化学
生物
断裂(地质)
古生物学
作者
Liangzhi Pang,Qilin Sun,Zhan Huang,Gen Li,Jiaojiao Liu,Jiaxu Guo,Chuan‐Zhi Yao,Jie Yu,Qiankun Li
标识
DOI:10.1002/anie.202211710
摘要
Abstract The transition‐metal‐catalyzed C−P bond cleavage has emerged as a powerful tool for the formation of both C−C and C−P bond. However, the transition‐metal‐catalyzed stereoselective cleavage of C−P bond is still undeveloped. Herein, we report a palladium‐catalyzed stereoselective cleavage of C−P bond for the construction of P‐stereogenic phosphines and stereogenic axis. This protocol enables the quick synthesis of atropisomers bearing a P‐stereogenic center in high yields, diastereo‐ and enantioselectivities of up to 98 % ee, >25 : 1 dr. The product is able to serve as chiral catalyst in phosphine catalyzed [3+2] cycloaddition of allenoates to imines, showing the great potential of the present methodology.
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