Chiral Metal–Organic Framework Hollow Nanospheres for High‐Efficiency Enantiomer Separation

Abstract Chiral ZIF‐8 hollow nanospheres with d ‐histidine as part of chiral ligands (denoted as H‐ d ‐his‐ZIF‐8) were prepared for separation of (±)‐amine acids. Compared to bulk d ‐his‐ZIF‐8 without a hollow cavity, the prepared H‐ d ‐his‐ZIF‐8 showed 15 times higher separation capacity and higher ee values of 90.5 % for alanine, 95.2 % for glutamic acid and 92.6 % for lysine, respectively.