生物
调解人
炎症
琥珀酸脱氢酶
疾病
线粒体
信号转导
病态的
免疫
病变
免疫学
免疫系统
内科学
内分泌学
病理
生物化学
医学
作者
Shulei Zhang,Yamin Liang,Li Lü,Yanmei Chen,Peng Wu,Dangheng Wei
标识
DOI:10.1089/dna.2021.0345
摘要
Succinate is an important intermediate product of mitochondrial energy metabolism. Recent studies revealed that beyond its known traditional metabolic functions, succinate plays important roles in signal transduction, immunity, inflammation, and posttranslational modification. Recent studies showed that patients and mouse models with cardiovascular disease have high levels of serum succinate and succinate accumulation. Atherosclerosis (As) is the pathological basis of cardiovascular and peripheral vascular diseases, such as coronary heart disease, cerebral infarction, and peripheral vascular disease, and is a major factor affecting human health. This article reviews the progression of succinate in As diseases and its underlying mechanisms.
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