DISEASE AND NON-DISEASE-RELATED RISK FACTORS FOR INADEQUATE BOWEL PREPARATION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: SHOULD THE STRATEGY BE DIFFERENT?

Aims Colonoscopy is of utmost importance in the management of inflammatory bowel disease(IBD). Most studies on inadequate bowel preparation(IBP) have not specifically evaluated the impact of IBD on the quality of bowel preparation. We aimed to identify disease and non-disease related factors for IBP in patients with IBD submitted to colonoscopy. Methods Retrospective cohort-study which included adult IBD patients submitted to colonoscopy between 2016-2021. Patients’ demographic, clinical, biochemical, and colonoscopy data were recorded. IBP was defined as a final Boston Bowel Preparation Scale≤5 or≤1 in at least one segment. A univariable analysis tested the association between covariables and the outcome(IBP) in general and considering Crohn’s disease(CD) and ulcerative colitis(UC) patients separately. Statistically significant variables were included in multivariable logistic binary regression. Results Of 309 patients, 51%(n=158) had UC and 48.9%(n=151) had CD. Eighty-two patients(27%) had IBP which was not significantly different between UC and CD patients (40vs42,p=0.699,respectively). The presence of diabetes mellitus (OR 13.9 [95%CI 1.388–139.624],p<0.05) and antidepressant use (OR 4.1 [95%CI 1.247–13.625],p<0.05) were independently associated with IBP in general. In contrast, only previous history of IBP (OR 3.1 [95%CI 1.184–8.271],p<0.05) was independently associated with IBP in UC patients. Disease-related factors such as previous surgery, steroids, immunosuppressors, biologics and endoscopic activity were not associated with IBP. Conclusions The presence of diabetes mellitus and antidepressant use are predictors of IBP for colonoscopy in patients with IBD. Disease-related factors seem to have no influence in the quality of bowel preparation suggesting that a specific approach is unnecessary in these patients. Publication History Article published online: 14 April 2022 © 2022. European Society of Gastrointestinal Endoscopy. All rights reserved. Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany