法尼甾体X受体
核受体
胆汁酸
超家族
代谢途径
癌变
平衡
肝X受体
生物
葡萄糖稳态
G蛋白偶联胆汁酸受体
受体
生物化学
细胞生物学
化学
生物信息学
内分泌学
新陈代谢
糖尿病
转录因子
基因
胰岛素抵抗
作者
Yanqiao Zhang,Peter A. Edwards
出处
期刊:FEBS Letters
[Wiley]
日期:2007-11-20
卷期号:582 (1): 10-18
被引量:180
标识
DOI:10.1016/j.febslet.2007.11.015
摘要
Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, has been shown to be important in controlling numerous metabolic pathways; these include roles in maintaining bile acid, lipid and glucose homeostasis, in preventing intestinal bacterial infection and gallstone formation and in modulating liver regeneration and tumorigenesis. The accumulating data suggest that FXR may be a pharmaceutical target for the treatment of certain metabolic diseases.
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