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生发中心
生物
滤泡树突状细胞
细胞生物学
细胞凋亡
免疫球蛋白E
抗体
受体
免疫系统
CD40
分子生物学
免疫学
B细胞
体外
抗原提呈细胞
细胞毒性T细胞
T细胞
生物化学
作者
Jean-Yves Bonnefoy,Sybille Henchoz,Debbie L. Hardie,Michelle J. Holder,John R. Gordon
标识
DOI:10.1002/eji.1830230432
摘要
Germinal center cells (GCC) are programmed to die by apoptosis unless they receive a positive signal for rescue. The primary signal in vivo is believed to be dependent on interaction with antigen held as immune complexes on follicular dendritic cells (FDC), a subset of which express large amounts of CD23, a low-affinity receptor for IgE. Recombinant soluble CD23 (sCD23) and interleukin-1 have been found to potentiate the survival of GCC in vitro. Recently, CD23 was shown to interact specifically with a ligand other than IgE, namely CD21 (CR2/Epstein-Barr virus receptor). In the present study, we show that a subset of anti-CD21 monoclonal antibodies behave similarly to soluble CD23 in their effect on GCC inasmuch as they: (i) diminish the occurrence of apoptosis; (ii) promote a plasmacytoid appearance in rescued cells; (iii) up-regulate expression of the Bcl-2 proto-oncogene. These findings indicate that FDC-derived CD23 exerts its effects on GCC via CD21.
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