纳米纤维素
生物相容性
防腐剂
抗菌剂
药物输送
抗菌活性
化学
药理学
生物医学工程
微生物学
医学
生物
细菌
生物化学
纤维素
遗传学
有机化学
作者
Sebastian Moritz,Cornelia Wiegand,Falko Wesarg,Nadine Heßler,Frank A. Müller,Dana Kralisch,Uta‐Christina Hipler,Dagmar Fischer
标识
DOI:10.1016/j.ijpharm.2014.04.062
摘要
Although bacterial nanocellulose (BNC) may serve as an ideal wound dressing, it exhibits no antibacterial properties by itself. Therefore, in the present study BNC was functionalized with the antiseptic drug octenidine. Drug loading and release, mechanical characteristics, biocompatibility, and antimicrobial efficacy were investigated. Octenidine release was based on diffusion and swelling according to the Ritger–Peppas equation and characterized by a time dependent biphasic release profile, with a rapid release in the first 8 h, followed by a slower release rate up to 96 h. The comparison between lab-scale and up-scale BNC identified thickness, water content, and the surface area to volume ratio as parameters which have an impact on the control of the release characteristics. Compression and tensile strength remained unchanged upon incorporation of octenidine in BNC. In biological assays, drug-loaded BNC demonstrated high biocompatibility in human keratinocytes and antimicrobial activity against Staphylococcus aureus. In a long-term storage test, the octenidine loaded in BNC was found to be stable, releasable, and biologically active over a period of 6 months without changes. In conclusion, octenidine loaded BNC presents a ready-to-use wound dressing for the treatment of infected wounds that can be stored over 6 months without losing its antibacterial activity.
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