上皮-间质转换
Wnt信号通路
SOX2
染色质免疫沉淀
转移
癌症研究
连环蛋白
连环素
细胞生物学
信号转导
生物
化学
癌症
转录因子
发起人
基因表达
基因
生物化学
遗传学
作者
Xuefei Li,Yingxi Xu,Yanan Chen,Si Chen,Xianpei Jia,Tongchao Sun,Yanhua Liu,Xiru Li,Rong Xiang,Na Li
出处
期刊:Cancer Letters
[Elsevier]
日期:2013-08-01
卷期号:336 (2): 379-389
被引量:160
标识
DOI:10.1016/j.canlet.2013.03.027
摘要
SOX2 was reported to promote metastasis in various tumor tissues; however the underlying mechanisms remain elusive. Here, we disclosed that SOX2 improves metastasis of breast and prostate cancer cells by promoting epithelial-to-mesenchymal transition (EMT) through WNT/β-catenin, but not TGF-β or Snail1 signaling. Dual luciferase assay and chromatin immunoprecipitation revealed activation and binding of SOX2 on promoter region of β-catenin. In addition, SOX2 affects the protein expression levels of DKK3, DVL1 and DVL3, which are regulators or downstream molecules of WNT signaling. Taken together, our findings demonstrated β-catenin as one of vital downstream molecules that mediate the EMT induced by SOX2.
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