医学
睡眠(系统调用)
内膜中层厚度
置信区间
内科学
人口
心脏病学
颈动脉
计算机科学
环境卫生
操作系统
作者
Birger Wolff,Henry Völzke,Christian Schwahn,Daniel M. Robinson,Christof Kessler,Ulrich John
标识
DOI:10.1016/j.atherosclerosis.2006.12.023
摘要
Objectives An association of sleep with cardiovascular disease has been suggested. We analyzed the association of sleep duration with carotid intima-media thickness (IMT) as measure of generalized atherosclerosis. Methods IMT of the common carotid arteries was measured in 2437 participants of the Study of Health in Pomerania (SHIP). Participants indicated their daily sleep duration as sum of night and afternoon sleep. Results There was a J-shaped association of sleep duration (5 to 11/12 h) with IMT. In this association, IMT values were lowest among subjects with an average sleep duration of 7–8 h (0.76 ± 0.15 and 0.79 ± 0.16 mm, respectively) but increased with shorter and, still more so, with longer sleep duration. Subjects with only 5 h sleep showed age- and sex-adjusted differences of 0.042 mm IMT (95% confidence interval 0.008–0.076 versus 8 h sleep). IMT values were still greater among subjects with 11–12 h sleep (adjusted differences versus 8 h sleep 0.084 mm [0.040–0.128] IMT). Further adjustment for lifestyle indicators, socioeconomic determinants, and biological variables attenuated these differences, but they remained significant. Conclusions Both longer and shorter sleep duration is associated with an increased risk of atherosclerosis. These findings support the hypothesis that sleep is related to cardiovascular disease.
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