条件基因敲除
生物
CD8型
基因剔除小鼠
功能(生物学)
T细胞
免疫学
基因敲除
谱系(遗传)
细胞命运测定
淋巴细胞亚群
Notch信号通路
基因
细胞生物学
信号转导
免疫系统
遗传学
转录因子
表型
作者
H. Robson MacDonald,Anne Wilson,Freddy Radtke
标识
DOI:10.1016/s1471-4906(00)01828-7
摘要
Notch proteins influence cell-fate decisions in many developmental systems. Gain-of-function studies have suggested a crucial role for Notch1 signaling at several stages during lymphocyte development, including the B/T, αβ/γδ and CD4/CD8 lineage choices. Here, we critically re-evaluate these conclusions in the light of recent studies that describe inducible and tissue-specific targeting of the Notch1 gene.
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