合成生物学
生物
信号通路
计算生物学
拟南芥
信号
系统生物学
表观遗传学
拟南芥
植物生物学
植物发育
植物科学
信号转导
基因
细胞生物学
遗传学
植物
突变体
作者
Jennifer L. Nemhauser,Keiko U. Torii
出处
期刊:Nature plants
[Springer Nature]
日期:2016-03-02
卷期号:2 (3)
被引量:52
标识
DOI:10.1038/nplants.2016.10
摘要
Molecular genetic studies of model plants in the past few decades have identified many key genes and pathways controlling development, metabolism and environmental responses. Recent technological and informatics advances have led to unprecedented volumes of data that may uncover underlying principles of plants as biological systems. The newly emerged discipline of synthetic biology and related molecular engineering approaches is built on this strong foundation. Today, plant regulatory pathways can be reconstituted in heterologous organisms to identify and manipulate parameters influencing signalling outputs. Moreover, regulatory circuits that include receptors, ligands, signal transduction components, epigenetic machinery and molecular motors can be engineered and introduced into plants to create novel traits in a predictive manner. Here, we provide a brief history of plant synthetic biology and significant recent examples of this approach, focusing on how knowledge generated by the reference plant Arabidopsis thaliana has contributed to the rapid rise of this new discipline, and discuss potential future directions.
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