Clinical study of comparative efficacy of DCF regimen vs. ECF regimen in treating advanced gastric cancer

Objective To evaluate the clinica1 efficacy and toxicity of docetaxo1 plus5Fu and cisplatin in the treatment of advanced gastric cancer.Methods Fifty-eight patients with advanced gastric cancer were randomly divided into 2groups.One group received docetaxol,5-Fu and cisplatin(DCF regimen,trial group),the other received epirubicin,5-Fu and cisplatin(ECF regimen,control group).Both regimens were repeated every 3 weeks.Results The tota1 response rate(CR + PR) was 36.6%(11 /30) in the trial group,and 28.5%(8 /28) in the control group.There was no significant difference between 2 groups(P 0.05).The main toxicity had no significant difference between 2 groups.Conclusion Docetaxol plus 5Fu and cisplatin were effective in treating advanced gastric cancer,the toxicity is mild and tolerable for most patients.