【Objectives】 To summarize and report the therapeutic effect by applying different types of flaps to repair the soft tissue defect in ankle and foot.【Methods】 Retrospectively analyzed clinical data that vascularized island flap or free flap to repair tissue defect in ankle and foot had been performed.【Results】 All of the 72 flaps survived,Transplantation of free flap were applied in 24 cases,and transplantation of vascularized island flap were performed in 48 cases.After follow up of 2 months to 16 months,the appearance and functional restoration and their protective sensation of ankle and foot are satisfactory.The transplanting skins of the donor area are endurable without lesion.【Conclusions】 Different types of surgical flaps can be used to repair the defect of ankle and foot depending on the location of the defect and the size of the wound.Choosing accurate flaps,preventing and managing vascular crisis is the key for optimal therapeutic effectiveness.