Prognosis of Idiopathic Thrombocytopenic Purpura in Serum Levels of Thrombopoietin and Number of Megakaryocyte

Objective To explore the prognosis of idiopathic thrombocytopenic purpura(ITP) in serum levels of thrombopoietin(TPO) and number of megakaryocyte.Methods Serum levels of TPO were measured with sandwich-enzyme linked immunosorbent assay kit.According to the number of megakaryocyte,the patients were divided into group A(the number of megakaryocyte was less than or equal to 35/6 cm~2) and group B(the number of megakaryocyte is higher than 35/6 cm~2) and reviewed their curative effects.Results The mean serum level of TPO in group A was(368.33±39.47) ng/L and that in group B was(141.48±11.28) ng/L.The serum levels of TPO in group A were visibly higher than those in group B.There was statistical difference between group A and group B(t=7.44 P0.01).The therapeutic effective power in group A was 23.8% and remarkably decreased than 84.2% in group B(χ~2=6.54 P0.05).The mean serum TPO levels in 5 responders in group A [(109.60±15.59) ng/L] was significantly lower than that in 16 nonresponder in group A[(449.18±29.59) ng/L] in treatment(t=-6.23 P0.01).Conclusions There is markedly difference in serum level of TPO in children with ITP.The high level of TPO and lower number of megakaryocyte prognosticated infaust prognosis in ITP.