光动力疗法
纳米载体
光敏剂
体内
活性氧
化学
紫杉醇
合理设计
体外
癌症治疗
癌症研究
生物物理学
药理学
药物输送
纳米技术
癌细胞
癌症
材料科学
生物化学
医学
生物
光化学
内科学
生物技术
有机化学
作者
Cong Luo,Bingjun Sun,Chen Wang,Xuanbo Zhang,Yao Chen,Qin Chen,Han Ye,Hanqing Zhao,Mengchi Sun,Zhenbao Li,Haotian Zhang,Qiming Kan,Yongjun Wang,He Zhang,Jin Sun
标识
DOI:10.1016/j.jconrel.2019.04.001
摘要
There is an urgent need to develop efficient combination drug delivery approaches to address the low efficiency of clinical cancer monotherapy. However, how to achieve high-efficient synchronous co-delivery and synergistic therapy remains a big challenge. Herein, we report a self-facilitated nanoassembly of a heterotypic chemo-photodynamic dimer for multimodal cancer therapy. A reactive oxygen species (ROS)-responsive dimer of paclitaxel (PTX) and pyropheophorbide a (PPa) is rationally designed and synthesized. The “Two-in-One” dimer serves as both carrier material and cargo, could self-assemble into nanoparticles in water with ultrahigh co-loading capacity and self-facilitated ROS-responsive drug release. The endogenous ROS overproduced in tumor cells together with PPa-generated ROS under laser irradiation synergistically facilitate on-demand drug release from the nano-assembly. The disintegration of nanoassembly triggered by ROS effectively addresses the dilemma of aggregation-caused quenching (ACQ) effect of photosensitizer (PPa). Both in vitro and in vivo results suggest that PTX-initiated chemotherapy in combination with PPa-mediated PDT exhibits synergistic antitumor activity. Our findings provide a strategy for the rational design of nanocarrier for high-efficient synergetic cancer therapy.
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