生物
白细胞介素-7受体
转录组
先天性淋巴细胞
先天免疫系统
免疫系统
免疫学
细胞
细胞生物学
单细胞测序
遗传学
基因
表型
T细胞
基因表达
白细胞介素2受体
外显子组测序
作者
Åsa K. Björklund,Marianne Forkel,Simone Picelli,Viktória Kónya,Jakob Theorell,Danielle Friberg,Rickard Sandberg,Jenny Mjösberg
摘要
Innate lymphoid cells (ILCs) are increasingly appreciated as important participants in homeostasis and inflammation. Substantial plasticity and heterogeneity among ILC populations have been reported. Here we have delineated the heterogeneity of human ILCs through single-cell RNA sequencing of several hundreds of individual tonsil CD127(+) ILCs and natural killer (NK) cells. Unbiased transcriptional clustering revealed four distinct populations, corresponding to ILC1 cells, ILC2 cells, ILC3 cells and NK cells, with their respective transcriptomes recapitulating known as well as unknown transcriptional profiles. The single-cell resolution additionally divulged three transcriptionally and functionally diverse subpopulations of ILC3 cells. Our systematic comparison of single-cell transcriptional variation within and between ILC populations provides new insight into ILC biology during homeostasis, with additional implications for dysregulation of the immune system.
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