细胞毒性
细胞凋亡
神经母细胞瘤
A549电池
钙钛矿(结构)
细胞生物学
化学
程序性细胞死亡
细胞
细胞生长
WI-38
癌症研究
细胞培养
纳米技术
材料科学
生物物理学
生物
生物化学
体外
倍性
基因
遗传学
结晶学
作者
Iness Benmessaoud,Anne Laure Mahul-Mellier,Endre Horváth,Bohumil Maco,Massimo Spina,Hilal A. Lashuel,Lászlø Forró
出处
期刊:Toxicology Research
[Oxford University Press]
日期:2016-01-01
卷期号:5 (2): 407-419
被引量:110
摘要
New technologies launch novel materials; besides their performances in products, their health hazards must be tested. This applies to the lead halide perovskite CH3NH3PbI3 as well, which offers fulgurate applications in photovoltaic devices. We report the effects of CH3NH3PbI3 photovoltaic perovskites in human lung adenocarcinoma epithelial cells (A549), human dopaminergic neuroblastoma cells (SH-SY5Y) and murine primary hippocampal neurons by using multiple assays and electron microscopy studies. In cell culture media the major part of the dissolved CH3NH3PbI3 has a strong cell-type dependent effect. Hippocampal primary neurons and neuroblastoma cells suffer a massive apoptotic cell death, whereas exposure to lung epithelial cells dramatically alters the kinetics of proliferation, metabolic activity and cellular morphology without inducing noticeable cell death. Our findings underscore the critical importance of conducting further studies to investigate the effect of short and long-term exposure to CH3NH3PbI3 on health and environment.
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