变色
生物
染色体重排
遗传学
基因组
癌变
基因复制
基因
染色体工程
基因重排
染色体
断点
计算生物学
基因组不稳定性
DNA
DNA损伤
核型
作者
Nicholas A. Willis,Emilie Rass,Ralph Scully
标识
DOI:10.1016/j.trecan.2015.10.007
摘要
Chromosome rearrangement plays a causal role in tumorigenesis by contributing to the inactivation of tumor suppressor genes, the dysregulated expression or amplification of oncogenes and the generation of novel gene fusions. Chromosome breaks are important intermediates in this process. How, when and where these breaks arise and the specific mechanisms engaged in their repair strongly influence the resulting patterns of chromosome rearrangement. Here, we review recent progress in understanding how certain distinctive features of the cancer genome, including clustered mutagenesis, tandem segmental duplications, complex breakpoints, chromothripsis, chromoplexy and chromoanasynthesis may arise.
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