Serum sex-hormone binding globulin (SHBG) and testosterone were measured in 52 samples from 15 female patients with anorexia nervosa. There was a significant correlation between body weight and serum levels of SHBG and testosterone. Moreover, the correlation between serum SHBG and relative weight 1055 suggests that serial measurement of serum SHBG might be a useful parameter in the management of patients with anorexia nervosa.