"Lights-Off" phenotype in Drosophila containing an UAS-A42 transgene.

Summary The UAS-A42 H29.3 transgenic Drosophila line used to model Alzheimer type neurodegeneration and other phenotypes falls down when transitioned from a light to a dark environment. This unusual phenotype is not dependent on the presence of a Gal4 driver and is thus unrelated to A42 induced proteotoxicity or neurodegeneration. We propose that it may instead be the result of disruption in another gene function caused by the P element insertion site. Since this transgenic line is used by several groups to analyze neurological phenotypes associated with A42 neuronal expression, the results of these studies must be interpreted with caution.