Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF‐1α in Psoriasis

Psoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor “hypoxia‐inducible factor 1‐alpha” (HIF‐1 α ) is involved in the homeostasis of these three biological phenomena. In this review, the role of HIF‐1 α in the cross talk between the cytokines and cells of the immunological system involved in the pathogenesis of psoriasis is discussed.