光动力疗法
单线态氧
材料科学
活性氧
微波食品加热
癌症治疗
溴化物
渗透(战争)
放射治疗
光化学
纳米技术
氧气
癌症研究
生物物理学
化学
癌症
计算机科学
医学
生物化学
有机化学
外科
电信
工程类
内科学
生物
运筹学
作者
Nil Kanatha Pandey,Xiong Wang,Lingyun Wang,Wei Chen,Brian Bui,Jian Yang,Eric Amador,Mingli Chen,Christina Xing,Aseem Athavale,Yaowu Hao,Wirya Feizi,Lloyd Lumata
标识
DOI:10.1016/j.bioactmat.2021.05.031
摘要
Aggregation-induced emission luminogens (AIEgens) exhibit efficient cytotoxic reactive oxygen species (ROS) generation capability and unique light-up features in the aggregated state, which have been well explored in image-guided photodynamic therapy (PDT). However, the limited penetration depth of light in tissue severely hinders AIEgens as a candidate for primary or adjunctive therapy for clinical applications. Coincidentally, microwaves (MWs) show a distinct advantage for deeper penetration depth in tissues than light. Herein, for the first time, we report AIEgen-mediated microwave dynamic therapy (MWDT) for cancer treatment. We found that two AIEgens (TPEPy-I and TPEPy-PF6) served as a new type of microwave (MW) sensitizers to produce ROS, including singlet oxygen (1O2), resulting in efficient destructions of cancer cells. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and live/dead assays reveal that the two AIEgens when activated by MW irradiation can effectively kill cancer cells with average IC-50 values of 2.73 and 3.22 μM, respectively. Overall, the ability of the two AIEgens to be activated by MW not only overcomes the limitations of conventional PDT, but also helps to improve existing MW ablation therapy by reducing the MW dose required to achieve the same therapeutic outcome, thus reducing the occurrence of side-effects of MW radiation.
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