电泳剂
烯醇
化学
试剂
Negishi偶联反应
催化作用
偶联反应
组合化学
乙醚
反应性(心理学)
镍
烯醇醚
砜
有机化学
替代医学
病理
医学
作者
Liang Gong,Qian Zhang,Demeng Xie,Wei Zhang,Shuo Xu,Xia Zhang,Dawen Niu
摘要
We describe here a Ni-catalyzed Negishi coupling reaction to prepare 1,2-dialkyl enol ethers in a stereoconvergent fashion. This method employs readily available and bench-stable α-oxy-vinylsulfones as electrophiles. The C-sulfone bond in the α-oxy-vinylsulfone motif is cleaved chemoselectively in these reactions. The mild conditions are tolerant of a variety of functional groups on both partners, thus representing a general strategy for enol ether synthesis. This unique reactivity of α-oxy-vinylsulfones indicates their further application as electrophilic partners in cross-coupling reactions.
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