藤黄蛋白C
Tenascin公司
细胞外基质
血管生成
细胞生物学
生物
组织修复
转移
病理
癌症研究
医学
癌症
纤维连接蛋白
遗传学
作者
Kim S. Midwood,Thomas Hussenet,Benoît Langlois,Gertraud Orend
标识
DOI:10.1007/s00018-011-0783-6
摘要
Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.
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