Advanced research on collagen cross-linking for reinforcing the sclera

The use of collagen cross-linking is being developed continually due to its significance in the improvement of the mechanical strength of collagen fibers and its role in stopping myopia progression. This article discusses the advantages and disadvantages of traditional scleral UVA riboflavin cross-linking and blue-light riboflavin scleral cross-linking. The trend toward blue-light scleral cross-linking in replacing UVA cross-linking to prevent the progression of myopia is described in this review article. Key words: Collagen; Cross-linking; Riboflavin; Blue-light; Sclera