化学
组合化学
催化作用
表面改性
基础(拓扑)
奥西多尔
区域选择性
有机催化
亲核细胞
环加成
作者
Basavaraja D,M S Ajay Krishna,Jagadeesh Krishnan,C S Athira,R R Amrutha,Eringathodi Suresh,Sasidhar B. Somappa
摘要
Base assisted divergent reactivity of isatins and allenoates has been achieved, which afforded diastereoselective spirofuran oxindoles and γ-functionalized allenoates. The DBU mediated Morita–Baylis–Hillman (MBH) reaction followed by the cascade annulation through the stabilized β-ammonium enolate intermediate led to the spiro-framework, wherein DABCO furnished the γ-functionalized allenoates. The protocol offers access to biologically relevant functionalized oxindole scaffolds with an excellent substrate scope under mild reaction conditions.
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